发明申请
US20110105478A1 NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS MODULATOR OF NICOTINIC ACETYLCHOLINE RECEPTORS
失效
新的1,4-二氮杂双环[3.2.2]有用的作为非线性乙酰胆碱受体的调节剂的NONYL OXADIAZOLYL衍生物
![NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS MODULATOR OF NICOTINIC ACETYLCHOLINE RECEPTORS](/docs/US/2011-05-05/US20110105478A1/abs.jpg.600x600.jpg)
- 专利标题： NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS MODULATOR OF NICOTINIC ACETYLCHOLINE RECEPTORS
- 专利标题（中）： 新的1,4-二氮杂双环[3.2.2]有用的作为非线性乙酰胆碱受体的调节剂的NONYL OXADIAZOLYL衍生物
-
申请号： US12921922申请日： 2009-03-09
-
公开(公告)号： US20110105478A1公开(公告)日： 2011-05-05
- 发明人: Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Eva Dam Christoffersen
- 申请人： Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Eva Dam Christoffersen
- 申请人地址： DK Ballerup
- 专利权人： NeuroSearch A/S
- 当前专利权人： NeuroSearch A/S
- 当前专利权人地址： DK Ballerup
- 优先权： DKPA200800372 20080311
- 国际申请： PCT/EP2009/052732 WO 20090309
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; C07D487/08 ; A61P25/00 ; A61P25/28 ; A61P25/24 ; A61P25/18 ; A61P3/04 ; A61P25/16 ; A61P29/00 ; A61P1/00 ; A61P11/06 ; A61P17/10
![NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS MODULATOR OF NICOTINIC ACETYLCHOLINE RECEPTORS](/abs-image/US/2011/05/05/US20110105478A1/abs.jpg.150x150.jpg)
摘要：
This invention relates to novel N-oxides of a 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivative and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
公开/授权文献
信息查询
