发明申请
- 专利标题: CARBOXYLIC DERIVATIVES FOR USE IN THE TREATMENT OF CANCER
- 专利标题(中): 用于治疗癌症的羧基衍生物
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申请号: US12735051申请日: 2008-12-18
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公开(公告)号: US20110105544A1公开(公告)日: 2011-05-05
- 发明人: Juan Aymami Bofarull , Franck Camille Nicolas Chevalier , Montserrat Soler Lopez , Maria Teresa Luque Garrofe , Marc Martinell Pedemonte
- 申请人: Juan Aymami Bofarull , Franck Camille Nicolas Chevalier , Montserrat Soler Lopez , Maria Teresa Luque Garrofe , Marc Martinell Pedemonte
- 优先权: EP07150330.4 20071221
- 国际申请: PCT/EP2008/067952 WO 20081218
- 主分类号: A61K31/216
- IPC分类号: A61K31/216 ; C07C69/612 ; C07C63/04 ; C07C63/33 ; C07C317/44 ; C07C229/42 ; C07D333/34 ; C07D213/55 ; A61K31/192 ; A61K31/195 ; A61K31/196 ; A61K31/381 ; A61K31/4402 ; A61P35/00
摘要:
The invention provides novel compounds of formula (I), wherein: R1 is a radical derived from one of the known ring systems; R2 is a phenyl radical optionally substituted; Xn represents a birradical selected from the group consisting of: —(CH2)1-4—, (C2-C4)-alkenyl, (C2-C4)alkynyl, —S—(CH2)1-3—#, and —(CH2)1-3—O—#; wherein the symbol # indicates the position at which Xn is attached to R1; Yn is a birradical selected from the group consisting of: —(CH2)2-4—, —S—(CH2)1-3#, and —O—(CH2)1-3—#; wherein the symbol # indicates the position at which Yn is attached to R2; and R3 is a radical selected from the group consisting of: —OR4. The compounds of formula (I) are useful in the treatment of cancer.
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