发明申请
US20110105731A1 Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
审中-公开
编码跨膜丝氨酸蛋白酶的核酸分子，编码的蛋白质和基于其的方法
- 专利标题： Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
- 专利标题（中）： 编码跨膜丝氨酸蛋白酶的核酸分子，编码的蛋白质和基于其的方法
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申请号： US12927372申请日： 2010-11-12
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公开(公告)号： US20110105731A1公开(公告)日： 2011-05-05
- 发明人: Edwin L. Madison , Edgar O. Ong , Jiunn-Chern Yeh
- 申请人： Edwin L. Madison , Edgar O. Ong , Jiunn-Chern Yeh
- 主分类号： C07K16/40
- IPC分类号： C07K16/40
摘要：
Provided herein are antibodies, fragments and derivatives of an antibody containing a binding domain thereof, where the antibody, fragment or derivative specifically binds to a single chain protease domain of a type II transmembrane serine protease (MTSP). Methods using the antibodies to modulate the protease activity of an MTSP are provided. Also provided are antibodies that bind to MTSPs designated MTSP3 and MTSP4 and to a form of an MTSP designated MTSP6.
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