Systems and techniques are disclosed for determining an intervention for a patient based at least in part on a likelihood of the patient to adhere to a prescription. In some implementations, a patient profile for a patient is obtained from one or more computer-readable storage devices in a patient population, the patient profile including multiple patient attributes; an adherence score is obtained for the patient profile, the adherence score for predicting patient adherence based on one or more of the multiple patient attributes wherein the adherence score indicates a likelihood of adherence of the patient to a prescribed treatment; and the adherence score obtained for the patient profile is modified into a modified score for intervention based on a set of weights for weighting the patient attributes.