发明申请
US20110117627A1 REGULATION OF APOPTOSIS BY NEURAL SPECIFIC SPLICE VARIANTS OF IG20
审中-公开
IG20神经特异性差异变异的调控
- 专利标题： REGULATION OF APOPTOSIS BY NEURAL SPECIFIC SPLICE VARIANTS OF IG20
- 专利标题（中）： IG20神经特异性差异变异的调控
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申请号： US13003215申请日： 2009-07-10
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公开(公告)号： US20110117627A1公开(公告)日： 2011-05-19
- 发明人: Bellur S. Prabhakar , Matthew N. Meriggioli , Liang Cheng LI
- 申请人： Bellur S. Prabhakar , Matthew N. Meriggioli , Liang Cheng LI
- 申请人地址： US IL Urbana
- 专利权人： The Board of Trustees of the University of Illinois
- 当前专利权人： The Board of Trustees of the University of Illinois
- 当前专利权人地址： US IL Urbana
- 国际申请： PCT/US09/50219 WO 20090710
- 主分类号： C12N7/01
- IPC分类号： C12N7/01 ; C07H21/02 ; C12N5/079 ; C12N5/10
摘要：
Pro-apoptotic signaling caused by down-modulation of KIAA0358 or expression of IG20-SV4 effectively induces spontaneous apoptosis and sensitization to TNFα-induced apoptosis in neuroblastoma cells. Methods and composition to enhance cell death in neuroblastoma are provided. Methods and compositions to reduce cell death in neurodegenerative disorders are provided.
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