发明申请
- 专利标题: Ligands of Estrogen Receptors alpha and beta, Method of Their Preparation, and Pharmaceuticals Comprising Them
- 专利标题(中): 雌激素受体α和β的配体,它们的制备方法和包括它们的药物
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申请号: US12990826申请日: 2009-05-05
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公开(公告)号: US20110118225A1公开(公告)日: 2011-05-19
- 发明人: Petr Novak , David Sedlak , Petr Bartunek , Martin Kotora
- 申请人: Petr Novak , David Sedlak , Petr Bartunek , Martin Kotora
- 优先权: CVPV2008275 20080505
- 国际申请: PCT/CZ2009/000066 WO 20090505
- 主分类号: A61K31/58
- IPC分类号: A61K31/58 ; C07J41/00 ; C07J17/00 ; A61K31/567 ; C07J43/00 ; C07J1/00 ; A61P35/00 ; A61P29/00 ; A61P5/00 ; A61P5/30
摘要:
The invention relates to novel ligands of the estrogen receptors α and β of general formula II, which are useful as an active substance of pharmaceuticals, for example pharmaceutical compositions useful for hormone replacement therapy, as well as for the treatment of tumors and inflammatory diseases. The invention also relates to a novel preparation method of these ligands comprising cyclotrimerization of ethynylestradiol with the appropriate diyne in an organic solvent. Further, the invention relates to pharmaceuticals comprising the novel compounds according to the invention.
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