发明申请
US20110130347A1 IDENTIFICATION OF NEW SPLICE-VARIANTS OF G-PROTEIN COUPLED RECEPTOR EP3 AND USES THEREOF
审中-公开
鉴定G蛋白偶联受体EP3的新型差异及其用途
- 专利标题： IDENTIFICATION OF NEW SPLICE-VARIANTS OF G-PROTEIN COUPLED RECEPTOR EP3 AND USES THEREOF
- 专利标题（中）： 鉴定G蛋白偶联受体EP3的新型差异及其用途
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申请号： US12602767申请日： 2008-05-20
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公开(公告)号： US20110130347A1公开(公告)日： 2011-06-02
- 发明人: Stefan Golz , Andreas Geerts
- 申请人： Stefan Golz , Andreas Geerts
- 申请人地址： DE Berlin
- 专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人地址： DE Berlin
- 优先权： EP07010926.9 20070602
- 国际申请： PCT/EP08/04007 WO 20080520
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C12Q1/68 ; C12N5/10 ; C12N15/63 ; G01N33/68 ; C07K14/47 ; C07H21/04 ; G01N33/53
摘要：
The present invention is directed to a polynucleotide sequence of the novel G-Protein Coupled Receptors EP3-11 OR EP3-12. The present invention provides polynucleotide sequences comprising the nucleic acid sequence SEQ ID NO: 20 or SEQ ID NO: 21 or nucleic acid sequences that hybridize to SEQ ID NO: 20 or SEQ ID NO: 21 or its complimentary strand having at least 40% sequence identity. The invention also provides the human EP3-11 or EP3-12 as targets for the identification of compounds useful for the treatment and prevention of cardiovascular diseases, inflammation, reproduction disorders and cancer as a result of relative quantification of the mRNA distribution in different human tissues by expression profiling. The invention also provides assays for the identification of compounds modulating EP3-11 or EP3-12.
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