发明申请
US20110135671A1 PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES
审中-公开
用于治疗过敏，炎性和感染性疾病的药物衍生物
- 专利标题： PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES
- 专利标题（中）： 用于治疗过敏，炎性和感染性疾病的药物衍生物
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申请号： US13058489申请日： 2009-08-07
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公开(公告)号： US20110135671A1公开(公告)日： 2011-06-09
- 发明人: Helene Bazin-Lee , Keith Biggadike , Diane Mary Coe , Xiao Qing Lewell , Charlotte Jane Mitchell , Naimisha Trivedi
- 申请人： Helene Bazin-Lee , Keith Biggadike , Diane Mary Coe , Xiao Qing Lewell , Charlotte Jane Mitchell , Naimisha Trivedi
- 申请人地址： US PA Philadelphia
- 专利权人： GLAXOSMITHKLINE LLC
- 当前专利权人： GLAXOSMITHKLINE LLC
- 当前专利权人地址： US PA Philadelphia
- 国际申请： PCT/EP2009/060263 WO 20090807
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07D473/18 ; C07D473/16 ; A61K31/522 ; A61P35/00 ; A61P31/00 ; A61P29/00 ; A61P37/08 ; A61P37/04
摘要：
The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 2 to 6; R2 is hydrogen, C1-6alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
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