发明申请
- 专利标题： Heterocyclic Compounds as CCR2 Antagonists
- 专利标题（中）： 杂环化合物作为CCR2拮抗剂
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申请号： US13018783申请日： 2011-02-01
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公开(公告)号： US20110136820A1公开(公告)日： 2011-06-09
- 发明人: Justin Fairfield Bower , Jeffrey Philip Poyser , Paul Turner , David Waterson , Jon Winter
- 申请人： Justin Fairfield Bower , Jeffrey Philip Poyser , Paul Turner , David Waterson , Jon Winter
- 申请人地址： SE Sodertalje
- 专利权人： ASTRAZENECA AB
- 当前专利权人： ASTRAZENECA AB
- 当前专利权人地址： SE Sodertalje
- 优先权： GB0428327.1 20041224; GB0520325.2 20051006
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61K31/506 ; A61P11/00 ; A61P11/06 ; A61P29/00 ; A61P19/10 ; A61P19/02
摘要：
Compounds of formula (I) Q-L-W—C(═X)—Z—P wherein Q is an amine of the formula —N(R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N—CN or S; Z is NR3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C—C chemokine mediated conditions.
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