发明申请
US20110144097A1 2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-PHENYL]-AMIDES
失效
2-氨基-5,5-二氟-5,6-二氢-4H- [1,3]氧杂-4-基） - 苯基] - 胺
![2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-PHENYL]-AMIDES](/docs/US/2011-06-16/US20110144097A1/abs.jpg.600x600.jpg)
- 专利标题： 2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-PHENYL]-AMIDES
- 专利标题（中）： 2-氨基-5,5-二氟-5,6-二氢-4H- [1,3]氧杂-4-基） - 苯基] - 胺
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申请号： US12959412申请日： 2010-12-03
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公开(公告)号： US20110144097A1公开(公告)日： 2011-06-16
- 发明人: David Banner , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Emmanuel Pinard , Eoin Power , Mark Rogers-Evans , Thomas Woltering , Wolfgang Wostl
- 申请人： David Banner , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Emmanuel Pinard , Eoin Power , Mark Rogers-Evans , Thomas Woltering , Wolfgang Wostl
- 优先权： EP09178983.4 20091211
- 主分类号： A61K31/5355
- IPC分类号： A61K31/5355 ; C07D413/12 ; C07D265/08 ; A61K31/535 ; A61P25/28 ; A61P3/10 ; A61P7/02 ; A61P35/00 ; A61P37/02 ; A61P29/00 ; A61P19/02 ; A61P9/00 ; A61P9/10
![2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-[1,3]OXAZIN-4-YL)-PHENYL]-AMIDES](/abs-image/US/2011/06/16/US20110144097A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to 2-Amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
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