发明申请
- 专利标题: NOVEL ADENINE DERIVATIVES
- 专利标题(中): 新的腺嘌呤衍生物
-
申请号: US13058465申请日: 2009-08-07
-
公开(公告)号: US20110144136A1公开(公告)日: 2011-06-16
- 发明人: Helene Bazin-Lee , Diane Mary Coe , Linos Lazarides , Charlotte Jane Mitchell , Stephen Allan Smith , Naimisha Trivedi
- 申请人: Helene Bazin-Lee , Diane Mary Coe , Linos Lazarides , Charlotte Jane Mitchell , Stephen Allan Smith , Naimisha Trivedi
- 申请人地址: US PA Philadelphia
- 专利权人: GLAXOSMITHKLINE LLC
- 当前专利权人: GLAXOSMITHKLINE LLC
- 当前专利权人地址: US PA Philadelphia
- 国际申请: PCT/EP09/60267 WO 20090807
- 主分类号: A61K31/522
- IPC分类号: A61K31/522 ; C07D473/18 ; C07D473/16 ; A61P29/00 ; A61P37/08
摘要:
The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure: n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the —(CH2)n— moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
公开/授权文献
- US08563717B2 Adenine derivatives 公开/授权日:2013-10-22