A method of transmitting data in a multiple antenna system includes transmitting first data through a first pilot pattern zone in which pilots are arranged in a specific pilot pattern in a permutation zone having at least one tile comprising a plurality of orthogonal frequency division multiplexing (OFDM) symbols and a plurality of subcarriers, and transmitting second data through a second pilot pattern zone in which pilots are arranged in another pilot pattern different from the pilot pattern of the first pilot pattern zone in the permutation zone. Accordingly, a plurality of pilot patterns can be simultaneously used in one permutation zone, and thus waste of radio resources caused by the use of unnecessary pilots can be reduced by adaptively assigning pilots according to various channel environments and performances of user equipments.