发明申请
- 专利标题: MUCOSAL MENINGOCOCCAL VACCINES
- 专利标题(中): 粘膜肉芽孢杆菌疫苗
-
申请号: US13036007申请日: 2011-02-28
-
公开(公告)号: US20110150923A1公开(公告)日: 2011-06-23
- 发明人: Giuseppe Del Giudice , Barbara Baudner , Derek O'Hagan
- 申请人: Giuseppe Del Giudice , Barbara Baudner , Derek O'Hagan
- 优先权: GB0302218.3 20030130; IBPCT/IB2003/002382 20030514
- 主分类号: A61K39/095
- IPC分类号: A61K39/095 ; A61K39/108 ; A61P31/04 ; A61K39/295
摘要:
The invention provides immunogenic compositions for mucosal delivery comprising capsular saccharides from at least two of serogroups A, C, W135 and Y of N. meningitidis. It is preferred that the capsular saccharides in the compositions of the invention are conjugated to carrier protein(s) and/or are oligosaccharides. Conjugated oligosaccharide antigens are particularly preferred. The invention also provides immunogenic compositions comprising (a) a capsular saccharide antigen from serogroup C of N. meningitidis, and (b) a chitosan adjuvant. The composition preferably comprises (c) one or more further antigens and/or (d) one or more further adjuvants. The compositions are particularly suitable for mucosal delivery, including intranasal delivery. The use of chitosan and/or detoxified ADP-ribosylating toxin adjuvants enhances anti-meningococcal mucosal immune responses and can shift the Th1/Th2 bias of the responses.
信息查询