发明申请
US20110150942A1 GASTRO-RESISTANT PHARMACEUTICAL ORAL COMPOSITIONS COMPRISING DULOXETINE OR ITS PHARMACEUTICALLY ACCEPTABLE DERIVATIVES
审中-公开
包含DULOXETINE或其药学上可接受的衍生物的耐药物药物口服组合物
- 专利标题： GASTRO-RESISTANT PHARMACEUTICAL ORAL COMPOSITIONS COMPRISING DULOXETINE OR ITS PHARMACEUTICALLY ACCEPTABLE DERIVATIVES
- 专利标题（中）： 包含DULOXETINE或其药学上可接受的衍生物的耐药物药物口服组合物
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申请号： US12997742申请日： 2009-06-12
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公开(公告)号： US20110150942A1公开(公告)日： 2011-06-23
- 发明人: Natalija Zajc , Franc Vrecer , Primoz Benkic , Polona Bukovec , Jaroslav Tihi , Andrej Gartner
- 申请人： Natalija Zajc , Franc Vrecer , Primoz Benkic , Polona Bukovec , Jaroslav Tihi , Andrej Gartner
- 优先权： EP08010804.6 20080613; EP08161169.1 20080725; EP08170847.1 20081205
- 国际申请： PCT/EP2009/057316 WO 20090612
- 主分类号： A61K31/381
- IPC分类号： A61K31/381 ; A61K9/00 ; C07D333/20 ; B65D85/00 ; B05D1/36 ; B05D5/00
摘要：
The present invention relates to a pharmaceutical composition comprising an active core comprising duloxetine or its pharmaceutically acceptable derivatives, a separating layer comprising a pH modifier and a gastro-resistant coating comprising a gastro-resistant polymer selected from methacrylic acid copolymers and optionally an over-coating layer. The present invention also relates to a process for the preparation of duloxetine hydrochloride. It also relates to a packaged medicament.
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