发明申请
US20110152256A1 1,2,4-TRIAZOLO[4,3-c]PYRIMIDIN-3-ONE AND PYRAZOLO[4,3-e]-1,2,4-TRIAZOLO[4,3-c]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
有权
1,2,4-三唑[4,3-c]嘧啶-3-酮和吡唑并[4,3-e] -1,2,4-三唑[4,3-c]吡啶-3-酮化合物 用作腺苷A2a受体拮抗剂
![1,2,4-TRIAZOLO[4,3-c]PYRIMIDIN-3-ONE AND PYRAZOLO[4,3-e]-1,2,4-TRIAZOLO[4,3-c]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS](/docs/US/2011-06-23/US20110152256A1/abs.jpg.600x600.jpg)
- 专利标题： 1,2,4-TRIAZOLO[4,3-c]PYRIMIDIN-3-ONE AND PYRAZOLO[4,3-e]-1,2,4-TRIAZOLO[4,3-c]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
- 专利标题（中）： 1,2,4-三唑[4,3-c]嘧啶-3-酮和吡唑并[4,3-e] -1,2,4-三唑[4,3-c]吡啶-3-酮化合物 用作腺苷A2a受体拮抗剂
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申请号： US12920924申请日： 2009-03-03
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公开(公告)号： US20110152256A1公开(公告)日： 2011-06-23
- 发明人: Joel M. Harris , Bernard R. Neustadt , Hong Liu , Jinsong Hao , Andrew W. Stamford
- 申请人： Joel M. Harris , Bernard R. Neustadt , Hong Liu , Jinsong Hao , Andrew W. Stamford
- 国际申请： PCT/US09/35839 WO 20090303
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D487/14 ; A61K31/519 ; C07D413/14 ; A61K31/497 ; C07D487/04 ; A61P25/16 ; A61P25/28
![1,2,4-TRIAZOLO[4,3-c]PYRIMIDIN-3-ONE AND PYRAZOLO[4,3-e]-1,2,4-TRIAZOLO[4,3-c]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS](/abs-image/US/2011/06/23/US20110152256A1/abs.jpg.150x150.jpg)
摘要：
Compounds of the Formula I wherein R1 and R2 together with the carbon atoms to which they are bonded optionally form a further heteroaromatic ring of the formula (II) as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof are adenosine A2a receptor antagonists and, therefore, are useful in the treatment of central nervous system diseases, in particular Parkinson's disease.
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