发明申请
- 专利标题： ETHYNYL COMPOUNDS USEFUL FOR TREATMENT OF CNS DISORDERS
- 专利标题（中）： 乙炔化合物可用于治疗中枢神经系统疾病
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申请号： US12964785申请日： 2010-12-10
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公开(公告)号： US20110152257A1公开(公告)日： 2011-06-23
- 发明人: Luke Green , Wolfgang Guba , Georg Jaeschke , Synese Jolidon , Lothar Lindermann , Heinz Stadler , Eric Vieira
- 申请人： Luke Green , Wolfgang Guba , Georg Jaeschke , Synese Jolidon , Lothar Lindermann , Heinz Stadler , Eric Vieira
- 优先权： EP09179719.1 20091217
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D487/04 ; C07D471/04 ; A61K31/437 ; A61K31/5377 ; A61P25/18 ; A61P25/16 ; A61P25/00 ; A61P25/24 ; A61P25/04 ; A61P25/30
摘要：
The present invention relates to ethynyl compounds of formula wherein X, Y, Z, and R4 are as defined herein or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5) and they are therefore useful for the treatment of diseases related to this receptor.
公开/授权文献
- US08586581B2 Ethynyl compounds useful for treatment of CNS disorders 公开/授权日：2013-11-19
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