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发明申请
US20110160281A1 RNA Interference Mediated Inhibition of Vascular Cell Adhesion Molecule (VCAM) Gene Expression Using Short Interfering Nucleic Acid (siNA) 有权
RNA干扰介导的使用短干扰核酸（siNA）的血管细胞粘附分子（VCAM）基因表达的抑制

RNA Interference Mediated Inhibition of Vascular Cell Adhesion Molecule (VCAM) Gene Expression Using Short Interfering Nucleic Acid (siNA)
摘要：
This invention relates to compounds, compositions, and methods useful for modulating vascular cell adhesion molecule gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of vascular cell adhesion molecule gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of vascular cell adhesion molecule genes, such as vascular cell adhesion molecule-1 (VCAM-1).
摘要（中）：

本发明涉及使用短干扰核酸（siNA）分子调节血管细胞粘附分子基因表达的化合物，组合物和方法。 本发明还涉及可用于通过使用小核酸分子调节涉及通过RNA干扰（RNAi）的血管细胞粘附分子基因表达和/或活性的途径的其它基因的表达和活性的方法。 特别地，本发明具有小的核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） 用于调节血管细胞粘附分子基因表达的分子和方法，如血管细胞粘附分子-1（VCAM-1）。

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