发明申请
US20110160459A1 5-ARYL-4,5-DIHYDRO-(1H)-PYRAZOLINES AS CANNABINOID CB1 RECEPTOR AGONISTS
审中-公开
5-ARYL-4,5-DIHYDRO-（1H） - 吡唑作为CANNABINOID CB1受体激动剂
- 专利标题： 5-ARYL-4,5-DIHYDRO-(1H)-PYRAZOLINES AS CANNABINOID CB1 RECEPTOR AGONISTS
- 专利标题（中）： 5-ARYL-4,5-DIHYDRO-（1H） - 吡唑作为CANNABINOID CB1受体激动剂
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申请号： US13042620申请日： 2011-03-08
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公开(公告)号： US20110160459A1公开(公告)日： 2011-06-30
- 发明人: Josephus H.M. LANGE , Hicham ZILAOUT , Bernard J. VAN VLIET
- 申请人： Josephus H.M. LANGE , Hicham ZILAOUT , Bernard J. VAN VLIET
- 专利权人： Solvay Pharmaceuticals, B.V.
- 当前专利权人： Solvay Pharmaceuticals, B.V.
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D231/06 ; C07D401/04
摘要：
The invention is directed to 5-(hetero)aryl-4,5-dihydro-(1H)-pyrazole (pyrazoline) derivatives as cannabinoid CB1 receptor agonists, to pharmaceutical compositions comprising these compounds, to methods for their syntheses, methods for preparing novel intermediates useful for their syntheses, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, administered to patients to achieve a therapeutic effect in disorders in which CB1 receptors are involved, or that can be treated via manipulation of those receptors.Compounds of the present invention include compounds of formula (I): wherein the substituents have the definitions given in the specification.
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