Invention Application
- Patent Title: PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES
- Patent Title (中): 制备取代的2-氨基 - 噻唑烷的方法
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Application No.: US12999961Application Date: 2009-06-16
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Publication No.: US20110160463A1Publication Date: 2011-06-30
- Inventor: George A. Moniz , Matthew J. Frizzle , Charles Bernard , Michael Martinelli , Margaret Faul , Jay Larrow , Karl B. Hansen , Liane Klingensmith
- Applicant: George A. Moniz , Matthew J. Frizzle , Charles Bernard , Michael Martinelli , Margaret Faul , Jay Larrow , Karl B. Hansen , Liane Klingensmith
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- International Application: PCT/US09/47469 WO 20090616
- Main IPC: C07D277/14
- IPC: C07D277/14
Abstract:
The present invention relates to methods of making compounds that inhibit 11-β-hydroxysteroid dehydrogenase type 1 enzyme (11-β HSD1). One method comprises (a) contacting a compound of formula (II) with a chiral base, deprotonating agent, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I); wherein Z, R1, R2, and R3 are defined herein.
Public/Granted literature
- US08536345B2 Process for making substituted 2-amino-thiazolones Public/Granted day:2013-09-17
Information query
