发明申请
- 专利标题： Cyclopamine Analogues and Methods of Use Thereof
- 专利标题（中）： 环吡胺类似物及其使用方法
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申请号： US12969024申请日： 2010-12-15
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公开(公告)号： US20110166353A1公开(公告)日： 2011-07-07
- 发明人: Julian Adams , Alfredo C. Castro , Michael A. Foley , Somarajan Nair Janardanan Nair , Marta Nevalainen , James R. Porter , Martin R. Tremblay
- 申请人： Julian Adams , Alfredo C. Castro , Michael A. Foley , Somarajan Nair Janardanan Nair , Marta Nevalainen , James R. Porter , Martin R. Tremblay
- 主分类号： C07D221/20
- IPC分类号： C07D221/20
摘要：
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
公开/授权文献
- US08236956B2 Cyclopamine analogues and methods of use thereof 公开/授权日：2012-08-07
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