发明申请
- 专利标题： ALGORITHMS FOR OUTCOME PREDICTION IN PATIENTS WITH NODE-POSITIVE CHEMOTHERAPY-TREATED BREAST CANCER
- 专利标题（中）： 患有结直肠癌治疗乳腺癌的患者的预后预测方法
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申请号： US12999522申请日： 2009-06-16
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公开(公告)号： US20110166838A1公开(公告)日： 2011-07-07
- 发明人: Mathias Gehrmann , Ralf Kronenwett , Udo Stropp , Christian Von Törne , Karsten Weber
- 申请人： Mathias Gehrmann , Ralf Kronenwett , Udo Stropp , Christian Von Törne , Karsten Weber
- 申请人地址： DE Koln
- 专利权人： Sividon Diagnostics
- 当前专利权人： Sividon Diagnostics
- 当前专利权人地址： DE Koln
- 优先权： EP08010916.8 20080616
- 国际申请： PCT/EP2009/057426 WO 20090616
- 主分类号： G06F7/60
- IPC分类号： G06F7/60
摘要：
The invention relates to methods for predicting an outcome of cancer in a patient suffering from cancer, said patient having been previously diagnosed as node positive and treated with cytotoxic chemotherapy, said method comprising determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CAl2, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF; ABCB1, ABCG2, ADAM15, AKR1C1, AKR1C3, AKT1, BANF1, BCL2, BIRC5, BRMS1, CASP10, CCNE2, CENPJ, CHPT1, EGFR, CTTN, ERBB3, ERBB4, FBLN1, FIP1L1, FLT1, FLT4, FNTA, GATA3, GSTP1, Herstatin, IGF1R, IGHM, KDR, KIT, CKRT5, SLC39A6, MAPK3, MAPT, MKI67, MMP7, MTA1, FRAP1, MUC1, MYC, NCOA3, NFIB, OLFM1, TP53, PCNA, PI3K, PPERLD1, RAB31, RAD54B, RAF1, SCUBE2, STAU, TINF2, TMSL8, VGLL1, TRA@, TUBA1, TUBB, TUBB2A.