An extracorporeal blood treatment device including a filter having a primary and a secondary chamber separated by a semi-permeable membrane, a withdrawal line connected to the primary chamber and associated to a first pump, a return line at the outlet of the primary chamber, a first pre-infusion line (109) connected to a citrate container on the withdrawal line (106), associated to a second pump, a first post-infusion line connected to a calcium solution container and to the return line, and associated to a third pump, an effluent line from the secondary chamber connected to a drain pipe and associated to a fourth pump, a CPU including first means programmed to receive the signal output by the pumps and second means programmed to control the third post-infusion pump (121) as a function of the input flow rate, effluent liquid flow rate, and anticoagulation liquid flow rate.