发明申请
- 专利标题： AMINE-BASED COMPOUND AND USE THEREOF
- 专利标题（中）： 基于胺的化合物及其用途
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申请号： US13051248申请日： 2011-03-18
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公开(公告)号： US20110172212A1公开(公告)日： 2011-07-14
- 发明人: Atsushi SAITOU , Shigeyuki Kikumoto , Masahiro Ono , Ryo Matsui , Masashi Yamamoto , Tomohiro Sawa , Shigeru Suzuki , Mikiro Yanaka
- 申请人： Atsushi SAITOU , Shigeyuki Kikumoto , Masahiro Ono , Ryo Matsui , Masashi Yamamoto , Tomohiro Sawa , Shigeru Suzuki , Mikiro Yanaka
- 申请人地址： JP Tokyo
- 专利权人： KUREHA CORPORATION
- 当前专利权人： KUREHA CORPORATION
- 当前专利权人地址： JP Tokyo
- 优先权： JP2004-068229 20040310; JP2004-350599 20041203
- 主分类号： A61K31/4178
- IPC分类号： A61K31/4178 ; C07D403/12 ; C07D403/14 ; A61K31/4184 ; C07D233/64 ; A61K31/417 ; C07D403/06 ; A61K31/5513 ; C07D401/12 ; A61K31/4439 ; C07D401/14 ; A61K31/4725 ; C07D471/04 ; A61K31/437 ; A61K31/454 ; A61K31/4709 ; C07D413/14 ; A61K31/5377 ; C07D405/14 ; A61P29/00 ; A61P35/04 ; A61P31/12 ; A61P31/18
摘要：
Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; typically, A1 and A2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and W represents a substitutable benzene ring or any group represented by the following formula (10) or (11): where X represents O, CH2, C(═O), NR11, or CHR35 and D represents a group represented by the following formula (6): [Formula 4] -Q-Y—B (6) where Q represents a single bond, NR12, or a group represented by the formula (13): and Y represents a group represented by the following formula (7): [Formula 6] —(CR18R19)m3- or —(CR20R21)m4-z-(CR22R23)m5- (7) where z represents a substitutable monocyclic or polycyclic aromatic ring; and B represents —NR25R26; and R1 to R26 in the above formulae represent a hydrogen atom, an alkyl group, an alkenyl group, or an alkynyl group.