发明申请
US20110172239A1 Compounds, Compositions and Methods for the Treatment of Amyloid Diseases and Synucleinopathies such as Alzheimer's Disease, Type 2 Diabetes and Parkinson's Disease
有权
用于治疗淀粉样疾病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法
- 专利标题： Compounds, Compositions and Methods for the Treatment of Amyloid Diseases and Synucleinopathies such as Alzheimer's Disease, Type 2 Diabetes and Parkinson's Disease
- 专利标题（中）： 用于治疗淀粉样疾病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法
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申请号： US12837721申请日： 2010-07-16
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公开(公告)号： US20110172239A1公开(公告)日： 2011-07-14
- 发明人: Alan D. SNOW , Beth NGUYEN , Gerardo CASTILLO , Virginia SANDERS , Thomas LAKE , Lesley LARSEN , Rex T. WEAVERS , Stephen LORIMER , David LARSEN , David L. COFFEN , Charlotte COFFEN
- 申请人： Alan D. SNOW , Beth NGUYEN , Gerardo CASTILLO , Virginia SANDERS , Thomas LAKE , Lesley LARSEN , Rex T. WEAVERS , Stephen LORIMER , David LARSEN , David L. COFFEN , Charlotte COFFEN
- 主分类号： A61K31/495
- IPC分类号： A61K31/495 ; C07C49/83 ; A61K31/12 ; A61P25/28 ; A61P25/00 ; A61P25/16 ; C07C39/16 ; A61K31/05 ; A61K31/4418 ; C07D213/85 ; C07D295/096 ; C07C215/50 ; A61K31/137 ; C07D451/06 ; A61K31/46 ; C07C235/50 ; A61K31/166
摘要：
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
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