发明申请
- 专利标题： METHODS FOR MODULATING EXPRESSION OF CREB
- 专利标题（中）： 调节CREB表达的方法
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申请号： US12993435申请日： 2009-05-22
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公开(公告)号： US20110177097A1公开(公告)日： 2011-07-21
- 发明人: Gerald Shulman , Sanjay Bhanot , Xing-Xian Yu , Brett P. Monia
- 申请人： Gerald Shulman , Sanjay Bhanot , Xing-Xian Yu , Brett P. Monia
- 国际申请： PCT/US09/45043 WO 20090522
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K31/7088 ; A61K38/02 ; A61K31/7125 ; A61K31/712 ; A61K31/7115 ; A61P3/00 ; A61P9/00 ; A61P3/06 ; A61P3/04 ; A61P3/10 ; A61P9/10 ; A61P1/16 ; A61P5/50
摘要：
Methods are provided for modulating CREB by administering a CREB-specific modulator. Also provided are methods for treating cardiovascular and metabolic disorders in a subject or delaying or preventing risk factors thereof through the modulation of CREB. The present invention is also directed to methods of decreasing lipid levels in a subject or for preventing or delaying the onset of a rise in lipid levels in a subject, comprising administering to said subject a CREB-specific inhibitor.
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