发明申请
US20110178056A1 SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS
有权
SPHINGOSINE 1磷酸盐受体调节剂及其合成方法
- 专利标题： SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS
- 专利标题（中）： SPHINGOSINE 1磷酸盐受体调节剂及其合成方法
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申请号： US12946800申请日： 2010-11-15
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公开(公告)号： US20110178056A1公开(公告)日： 2011-07-21
- 发明人: Esther MARTINBOROUGH , Marcus F. Boehm , Adam Richard Yeager , Junko Tamiya , Liming Huang , Enugurthi Brahmachary , Manisha Moorjani
- 申请人： Esther MARTINBOROUGH , Marcus F. Boehm , Adam Richard Yeager , Junko Tamiya , Liming Huang , Enugurthi Brahmachary , Manisha Moorjani
- 主分类号： A61K31/4245
- IPC分类号： A61K31/4245 ; C07D271/06 ; C07D413/12 ; A61K31/5377 ; A61K31/454 ; A61P25/00 ; A61P37/06 ; A61P11/00 ; A61P1/00 ; A61P1/04 ; A61P31/16
摘要：
Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.