The initialization of an inertial navigation system is performed using information obtained from an image of an object. Positional and orientational information about the object in a global reference frame and positional and orientational information about the camera relative to the object are obtained from the image. Positional and orientational information for the camera in the global reference frame is determined along with a transformation matrix between inertial sensor reference frame and a navigation coordinate frame. The inertial navigation system is initialized using the positional and orientational information for the camera, the transformation matrix and the velocity of the camera when the object was imaged, i.e., zero. Using the initialized data with measurements from the inertial sensors the position of the mobile platform may be updated during navigation and provided, e.g., on a digital map. Inertial navigation errors may be corrected using information obtained from images of different objects.