发明申请
- 专利标题： Icotinib Hydrochloride, Synthesis, Crystalline Forms, Pharmaceutical Compositions, and Uses Thereof
- 专利标题（中）： 盐酸伊可啶，合成，结晶形式，药物组合物及其用途
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申请号： US13003216申请日： 2009-07-07
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公开(公告)号： US20110182882A1公开(公告)日： 2011-07-28
- 发明人: Yinxiang Wang , Guojian Xie , Lieming Ding , Fenlai Tan , Yunyan Hu , Wei He , Bin Han , Wei Long , Yong Liu , Haima Ai , Charles Davis , Don Zhang
- 申请人： Yinxiang Wang , Guojian Xie , Lieming Ding , Fenlai Tan , Yunyan Hu , Wei He , Bin Han , Wei Long , Yong Liu , Haima Ai , Charles Davis , Don Zhang
- 申请人地址： US CT Branford
- 专利权人： Beta Pharma, Inc.
- 当前专利权人： Beta Pharma, Inc.
- 当前专利权人地址： US CT Branford
- 优先权： CN200810132631.3 20080708; CN200810131458.7 20080717; CN200810188272.3 20081223
- 国际申请： PCT/CN09/00773 WO 20090707
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07D491/056 ; A61K31/519 ; A61K38/43 ; A61P35/00
摘要：
The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride.