- 专利标题： O-BENZYL NICOTINAMIDE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS
-
申请号： US12886950申请日： 2010-09-21
-
公开(公告)号： US20110183980A1公开(公告)日： 2011-07-28
- 发明人: P. Jeffrey Conn , Craig W. Lindsley , Charles David Weaver , Shaun Stauffer , Richard Williams , Gregor MacDonald , Ya Zhou , José Manuel Bartolomé-Nebreda
- 申请人： P. Jeffrey Conn , Craig W. Lindsley , Charles David Weaver , Shaun Stauffer , Richard Williams , Gregor MacDonald , Ya Zhou , José Manuel Bartolomé-Nebreda
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D213/62 ; C07D213/78 ; C07D401/12 ; C07D417/12 ; C07D403/12 ; C07D413/12 ; A61K31/444 ; A61K31/44 ; A61K31/4427 ; A61K31/4439 ; A61K31/506 ; A61P25/00
摘要：
In one aspect, the invention relates to O-benzyl nicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
信息查询
IPC分类:
