A computer pointing device is adapted for use with a computer to control position of a cursor on a screen. The computer pointing device includes a casing, a macro key mounted operably on the casing, a storage medium disposed in the casing and storing a macro command, an execution module disposed in the casing, and a transmission interface. The macro command corresponds to the macro key and specifies an instruction set for controlling the cursor to move to a point defined by predetermined absolute coordinates on the screen. The execution module is coupled electrically to the macro key and the storage medium, and is operable to execute the macro command when the macro key is operated so as to generate an output signal corresponding to the macro command. The transmission interface is coupled electrically to the execution module and is operable to transmit the output signal to the computer.