During a conference, a multipoint control unit (MCU) designates priority and non-priority endpoints. The MCU forms priority audio from the priority endpoint and sends that audio to the other endpoints at a normal level. However, the MCU forms non-priority audio from the non-priority endpoint and handles that audio based on whether the input audio from the priority endpoint is from speaking or not. If the priority endpoint's audio indicates a participant at that endpoint is speaking, then the MCU sends the non-priority audio to the other endpoints at a reduced level. Designation of which endpoint has priority can be based on which endpoint has a current duration of audio indicative of speech that is longer than other endpoints. Alternatively, the designation can be based on which endpoint is currently presenting content during the conference or based on a mix of speech audio and content presentation.