A hydrogen generation device and a fuel cell using the same are provided. The hydrogen generation device includes a first containing groove, a cover, a second containing groove, and a rotating device. The first containing groove contains liquid water. The cover is fixed on the first containing groove and covers the liquid water. The cover has an opening for exposing the liquid water. The second containing groove is stacked on the cover and divided into a plurality of containing compartments, wherein each containing compartment contains a solid fuel. The opening is aligned with one containing compartment so that the corresponding solid fuel reacts with the liquid water generate hydrogen. The rotating device is connected with the first or the second containing groove. The opening is moved and aligned with another containing compartment when the rotating device drives the first containing groove and the second containing groove to relatively rotate.