When adjusting parameters of a segmentation protocol for segmenting a volume of interest in an anatomical image, a user selects a superparameter (50) that includes multiple internal parameters (52) for adjusting a raw segmentation of the volume interest. As a weight of the selected superparameter is adjusted, weights of the internal parameters associated with the superparameter are adjusted according to a superparameter segmentation adjustment algorithm (20). The volume of interest is iteratively re-segmented after each internal parameter adjustment, transparently to the user, until a predetermined amount of change has been effected in the volume of interest segmentation, at which time the re-segmented volume of interest is displayed to the user.