发明申请
US20110195506A1 METHOD FOR PRODUCING YEAST EXPRESSED HPV TYPES 6 AND 16 CAPSID PROTEINS
审中-公开
用于生产YEAST EXPRESSED HPV HPV 6型和16型CAPSID蛋白的方法
- 专利标题： METHOD FOR PRODUCING YEAST EXPRESSED HPV TYPES 6 AND 16 CAPSID PROTEINS
- 专利标题（中）： 用于生产YEAST EXPRESSED HPV HPV 6型和16型CAPSID蛋白的方法
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申请号： US13005265申请日： 2011-01-12
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公开(公告)号： US20110195506A1公开(公告)日： 2011-08-11
- 发明人: Daniela Tornese BUONAMASSA , Catherine E. Greer , Cesira L. Galeotti , Giuliano Bensi , Roberto Petracca
- 申请人： Daniela Tornese BUONAMASSA , Catherine E. Greer , Cesira L. Galeotti , Giuliano Bensi , Roberto Petracca
- 主分类号： C12N15/81
- IPC分类号： C12N15/81 ; C12N1/19
摘要：
Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLPs induced the production of conformational antibodies against both L1 proteins upon administration to mice.
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