A device for mixing and discharging plural materials has a body, a housing and a sealing plug. The body has multiple barrels and multiple tubes communicating with the barrels. The housing is rotatably attached to the body in a thread manner and has a mixing chamber and a discharging segment. The sealing plug is mounted in the mixing chamber to seal the tubes and has a sealing disk and multiple sealing sleeves. The sealing disk has multiple holes and multiple sealing lids mounted respectively in the holes, and each sealing lid has an outer edge connected detachably to the inner surface of a corresponding hole and having a thickness smaller than that of the sealing lid. The sealing sleeves are formed on the sealing disk, align respectively with the holes in the sealing disk and are mounted respectively around the tubes.