发明申请
US20110200586A1 AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS
有权
作为雌激素相关受体 - 阿尔法调节剂的氨基丁糖
- 专利标题: AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS
- 专利标题(中): 作为雌激素相关受体 - 阿尔法调节剂的氨基丁糖
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申请号: US13028266申请日: 2011-02-16
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公开(公告)号: US20110200586A1公开(公告)日: 2011-08-18
- 发明人: Gilles BIGNAN , Micheal Gaul , Guozhang Xu , Bao-Ping Zhao
- 申请人: Gilles BIGNAN , Micheal Gaul , Guozhang Xu , Bao-Ping Zhao
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07D417/10 ; C07D417/14 ; C07D413/14 ; A61K31/427 ; A61K31/4439 ; A61K31/454 ; A61K31/496 ; A61K31/5377 ; A61K31/4985 ; A61P19/08 ; A61P19/06 ; A61P19/10 ; A61P35/04 ; A61P35/00 ; A61P19/02 ; A61P17/06 ; A61P29/00 ; A61P11/00 ; A61P1/02 ; A61P3/00 ; A61P3/04 ; A61P3/10 ; A61P9/00 ; A61P9/10 ; A61P7/02
摘要:
The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.