发明申请
US20110201048A1 SCREENING METHOD OF THERAPEUTIC AND DIAGNOSTIC AGENTS FOR TNF-ALPHA-INDUCED DISEASES USING REACTIVE OXYGEN SPECIES MODULATOR 1
审中-公开
使用反应性氧化物质调节剂1的TNF-ALPHA诱导的疾病的治疗和诊断试剂的筛选方法
- 专利标题： SCREENING METHOD OF THERAPEUTIC AND DIAGNOSTIC AGENTS FOR TNF-ALPHA-INDUCED DISEASES USING REACTIVE OXYGEN SPECIES MODULATOR 1
- 专利标题（中）： 使用反应性氧化物质调节剂1的TNF-ALPHA诱导的疾病的治疗和诊断试剂的筛选方法
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申请号： US13126421申请日： 2010-01-11
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公开(公告)号： US20110201048A1公开(公告)日： 2011-08-18
- 发明人: Young-Do Yoo , Jung-Jin Kim
- 申请人： Young-Do Yoo , Jung-Jin Kim
- 申请人地址： KR Seoul
- 专利权人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
- 当前专利权人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
- 当前专利权人地址： KR Seoul
- 优先权： KR10-2009-0062255 20090708
- 国际申请： PCT/KR10/00141 WO 20100111
- 主分类号： C12Q1/02
- IPC分类号： C12Q1/02 ; G01N33/50 ; G01N33/53
摘要：
Disclosed are methods for screening therapeutics, prophylactics or pain alleviators for diseases induced by TNF-α, a main mediator of inflammation and in ROS production and cell death, and for diagnosing the diseases, and a diagnostic kit. For this, a nucleotide sequence and an amino acid sequence of Romo1, which plays an important role in the ROS production and cell death pathway of TNF-α signaling are utilized.