发明申请
- 专利标题: Molecular Probe for Imaging of Pancreatic Islets and Use of the Same
- 专利标题(中): 胰岛成像用分子探针及其用途
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申请号: US12964486申请日: 2010-12-09
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公开(公告)号: US20110206605A1公开(公告)日: 2011-08-25
- 发明人: Hideo Saji , Nobuya Inagaki , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
- 申请人: Hideo Saji , Nobuya Inagaki , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
- 申请人地址: JP Kyoto JP Kyoto
- 专利权人: Kyoto University,ARKRAY, Inc.
- 当前专利权人: Kyoto University,ARKRAY, Inc.
- 当前专利权人地址: JP Kyoto JP Kyoto
- 优先权: JPJP2009-280396 20091210; JPJP2010-125983 20100601
- 主分类号: A61K51/08
- IPC分类号: A61K51/08 ; C07K14/00 ; C07K1/13 ; C12Q1/02
摘要:
A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe comprises a polypeptide represented by the following formula (1), (2), or (3), or a polypeptide having homology with the foregoing polypeptide, (SEQ ID NO. 1) Z-HGEGTFTSDLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (1) (SEQ ID NO. 2) Z-HGEGTFTSDLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH2 (2) (SEQ ID NO. 3) B-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (3) where, in the formulae (1) and (2), “X” represents a lysine residue, an amino group of a side chain of the lysine residue being labeled with a radioactive nuclide, and “Z—” indicates that an α-amino group at an N-terminus is not modified, or is modified with a modifying group having no electric charge; in the formula (3), “B—” indicates that an α-amino group at an N-terminus is labeled with a radioactive nuclide; and in the formulae (1), (2), and (3), “—NH2” indicates that a carboxyl group at a C-terminus is amidated.