发明申请
- 专利标题： ENHANCED ANTISENSE OLIGONUCLEOTIDES
- 专利标题（中）： 增强反义寡核苷酸
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申请号： US13008704申请日： 2011-01-18
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公开(公告)号： US20110207797A1公开(公告)日： 2011-08-25
- 发明人: Brett P. Monia , Andrew M. Siwkowski , Sanjay Bhanot
- 申请人： Brett P. Monia , Andrew M. Siwkowski , Sanjay Bhanot
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; A61P9/00 ; A61P3/00 ; A61P3/10 ; A61P3/04 ; A61P3/06 ; A61P1/16 ; A61P9/10 ; A61P9/12 ; A61P7/02
摘要：
Described herein are gap-widened antisense oligonucleotides having improved therapeutic index as compared to 5-10-5 MOE gapmer antisense oligonucleotides of the same sequence. Also described are methods of reducing a target RNA in an animal using the gap-widened antisense oligonucleotides of the present invention. Further, are methods for selecting a gap-widened antisense oligonucleotides.
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