发明申请
- 专利标题: COMPOUND HAVING TAFIA INHIBITORY ACTIVITY
- 专利标题(中): 具有TAFIA抑制活性的化合物
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申请号: US13126685申请日: 2009-10-28
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公开(公告)号: US20110213143A1公开(公告)日: 2011-09-01
- 发明人: Hideaki Amada , Daisuke Matsuda , Masahiro Bohno , Shiuji Saito , Ayako Bohno
- 申请人: Hideaki Amada , Daisuke Matsuda , Masahiro Bohno , Shiuji Saito , Ayako Bohno
- 申请人地址: JP Toshima-ku, Tokyo
- 专利权人: TAISHO PHARMACEUTICAL CO., LTD.
- 当前专利权人: TAISHO PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Toshima-ku, Tokyo
- 优先权: JP2008-278302 20081029
- 国际申请: PCT/JP2009/068526 WO 20091028
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; C07D471/04 ; C07D498/04 ; C07D471/14
摘要:
Provided are compounds having superior TAFIa inhibitory activity. Specifically, there are provided compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof: wherein A is a benzene ring or a pyridine ring; X is the formula —(CH2)—, the formula —(CH2)2—, an oxygen atom, a nitrogen atom or a single bond; Y is the formula —(CH2)3—NH—R3, the formula —(CH2)4—NH—R3 or a 2-aminopyridyl group; R3 is a hydrogen atom, a C1-6 alkyl group, or the formula —CO2R4; R4 is a C1-6 alkyl group, the formula —CHR5OC(O)R6, or a substituent having the structure represented by the following formula Ia; R5 is a C1-6 alkyl group; R6 is a C1-6 alkyl group, a C3-8 cycloalkyl group, or a phenyl group; R7 is a C1-6 alkyl group or a phenyl group; R1 is a hydrogen atom, a halogen atom, a C1-4 alkyl group substituted by 1-3 halogen atoms, a C1-10 alkyl group, a C1-8 alkoxy group, a C3-8 cycloalkyl group, a C3-8 cycloalkoxy group, a C4-14 cycloalkylalkyl group, or a phenyl group; R2 is CO2R8, or a tetrazolyl group; R8 is a hydrogen atom, a C1-10 alkyl group, or a substituent having the structure represented by the following formula Ib or Ic; m and n are each an integer of zero or one.
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