发明申请
US20110217459A1 Process for conjugating biomolecules to hydrophobic membrane-incorporated molecules
审中-公开
将生物分子与疏水性膜结合分子结合的方法
- 专利标题: Process for conjugating biomolecules to hydrophobic membrane-incorporated molecules
- 专利标题(中): 将生物分子与疏水性膜结合分子结合的方法
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申请号: US11974970申请日: 2007-10-16
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公开(公告)号: US20110217459A1公开(公告)日: 2011-09-08
- 发明人: Basil I. Swanson , Clifford J. Unkefer , Jurgen G. Schmidt , Scott M. Reed , John E. Shively , Lin Li
- 申请人: Basil I. Swanson , Clifford J. Unkefer , Jurgen G. Schmidt , Scott M. Reed , John E. Shively , Lin Li
- 主分类号: B05D5/06
- IPC分类号: B05D5/06
摘要:
A process is provided of conjugating a recognition element such as a biomolecule to a hydrophobic multifunctional linker molecule by incorporating a multifunctional linker molecule including one or more anchoring groups, a reporter group and a reactive site thereon into a membrane, and, reacting the membrane including the incorporated multifunctional linker molecule with a pre-selected recognition element to form a covalently bound recognition element-multifunctional linker molecule-membrane assembly. Also, a chemical assembly suitable for subsequent covalent attachment of a recognition element is provided such assembly including a multifunctional linker molecule including one or more anchoring groups, a reporter group, and a hydrophilic spacer terminated by a reactive group capable of subsequent covalent bonding, the one or more anchoring groups incorporated in a membrane.
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