发明申请
- 专利标题： INHIBITORS OF TYROSINE KINASES
- 专利标题（中）： TYROSINE KINASES的抑制剂
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申请号： US13106582申请日： 2011-05-12
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公开(公告)号： US20110218187A1公开(公告)日： 2011-09-08
- 发明人: Werner BREITENSTEIN , Pascal FURET , Sandra JACOB , Paul William MANLEY
- 申请人： Werner BREITENSTEIN , Pascal FURET , Sandra JACOB , Paul William MANLEY
- 优先权： GB0215676.8 20020705; GB0229893.3 20021220
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D401/04 ; A61K31/506 ; A61K31/496 ; C07D401/14 ; C07D413/14 ; A61K31/5377 ; A61P35/02
摘要：
The invention relates to compounds of formula wherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, especially a neoplastic disease, in particular leukaemia, and a method for the treatment of such a disease.
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