An electronic device with latching mechanism comprises a cover, a base, and a middle case located between the cover and the base. The cover on edges defines a plurality of protruding tabs each with a through hole. The base defines a plurality of hooks. The middle case on the inner surface defines a plurality of protruding portions corresponding to the protruding tabs of the cover in number and arrangement, and a plurality of limiting portions corresponding to the hooks of the base in number and arrangement. The protruding portions each with an angled surface angling toward the cover are received in the through holes of the cover. The limiting portions engage the hooks of the base.