发明申请
- 专利标题： COMBINATIONS OF PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND CHEMOTHERAPEUTIC AGENTS, AND METHODS OF USE
- 专利标题（中）： 磷酸三辛酯抑制剂化合物和化学治疗剂的组合及使用方法
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申请号： US13109670申请日： 2011-05-17
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公开(公告)号： US20110223619A1公开(公告)日： 2011-09-15
- 发明人: Marcia Belvin , Lori Friedman , Klaus Hoeflich , Deepak Sampath , Ulka Vijapurkar , Jeffrey Wallin , Leisa Johnson , Mallika Singh , Sonal Patel
- 申请人： Marcia Belvin , Lori Friedman , Klaus Hoeflich , Deepak Sampath , Ulka Vijapurkar , Jeffrey Wallin , Leisa Johnson , Mallika Singh , Sonal Patel
- 申请人地址： US CA South San Francisco CH Basel
- 专利权人： Genentech, Inc.,F. Hoffmann-La Roche AG
- 当前专利权人： Genentech, Inc.,F. Hoffmann-La Roche AG
- 当前专利权人地址： US CA South San Francisco CH Basel
- 主分类号： G01N33/574
- IPC分类号： G01N33/574 ; C12Q1/02
摘要：
Combinations of PI3K inhibitor compounds having Formulas I and II and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hyperproliferative disorders such as cancer. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.