发明申请
- 专利标题: INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE
- 专利标题(中): 二乙酰胆碱酯酶抑制剂
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申请号: US13129843申请日: 2009-11-17
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公开(公告)号: US20110224137A1公开(公告)日: 2011-09-15
- 发明人: Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
- 申请人: Pauline C. Ting , Robert Aslanian , Mary Ann Caplen , Jianhua Cao , Tin-Yau Chan , David Kim , Hyunjin Kim , Jae-Hun Kim , Rongze Kuang , Joe F. Lee , John Schwerdt , Heping Wu , Nicolas Zorn
- 国际申请: PCT/US2009/064738 WO 20091117
- 主分类号: A61K38/28
- IPC分类号: A61K38/28 ; C07D409/14 ; C07D243/08 ; C07D401/14 ; C07D221/00 ; C07D211/06 ; A61K31/497 ; A61K31/551 ; A61K31/4545 ; A61K31/438 ; A61K31/454 ; A61P3/04 ; A61P3/10
摘要:
The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below: formula (I).
公开/授权文献
- US08716312B2 Inhibitors of diacylglycerol acyltransferase 公开/授权日:2014-05-06