发明申请
- 专利标题: CGRP RECEPTOR ANTAGONISTS
- 专利标题(中): CGRP受体拮抗剂
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申请号: US13121784申请日: 2009-09-29
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公开(公告)号: US20110224201A1公开(公告)日: 2011-09-15
- 发明人: Donnette D. Staas , Ian M. Bell , Harold G. Selnick
- 申请人: Donnette D. Staas , Ian M. Bell , Harold G. Selnick
- 国际申请: PCT/US09/58711 WO 20090929
- 主分类号: A61K31/537
- IPC分类号: A61K31/537 ; C07D498/20 ; C07D498/04 ; A61P25/06 ; A61P25/00
摘要:
Compounds of Formula (I), (wherein variables A1, A2, A3, A4, A5, A6, A7, A8, L, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG, W, Y and Z are as described herein) useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.
公开/授权文献
- US08685965B2 CGRP receptor antagonists 公开/授权日:2014-04-01
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