发明申请
US20110229470A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISEASE SECONDARY TO MULTIPLE SCLEROSIS
审中-公开
多发性硬化症的自身免疫性疾病诊断和治疗方法与组合
- 专利标题： METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISEASE SECONDARY TO MULTIPLE SCLEROSIS
- 专利标题（中）： 多发性硬化症的自身免疫性疾病诊断和治疗方法与组合
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申请号： US13123188申请日： 2009-10-08
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公开(公告)号： US20110229470A1公开(公告)日： 2011-09-22
- 发明人: Alasdair J. Coles , Joanne L. Jones , Alastair Compston
- 申请人： Alasdair J. Coles , Joanne L. Jones , Alastair Compston
- 申请人地址： GB Cambridge
- 专利权人： CAMBRIDGE ENTERPRISE
- 当前专利权人： CAMBRIDGE ENTERPRISE
- 当前专利权人地址： GB Cambridge
- 国际申请： PCT/IB2009/007327 WO 20091008
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; G01N33/566 ; C12Q1/68 ; C12Q1/37 ; A61P37/06 ; A61P25/00
摘要：
The invention provides methods of diagnosing multiple sclerosis (MS) patients, including methods of identifying multiple sclerosis patients who are at increased risk of developing a secondary autoimmune disease following lymphocyte depletion, caused, e.g., by treatment with an anti-CD52 antibody. Also embraced are methods of selecting treatment regimens for MS patients, and reagents useful in the above methods.
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