发明申请
US20110229495A1 METHODS FOR PREDICTING DEVELOPMENT OF AUTO-IMMUNE DISEASES AND TREATMENT OF SAME
审中-公开
预防自身免疫疾病发展及其治疗的方法
- 专利标题： METHODS FOR PREDICTING DEVELOPMENT OF AUTO-IMMUNE DISEASES AND TREATMENT OF SAME
- 专利标题（中）： 预防自身免疫疾病发展及其治疗的方法
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申请号： US12397063申请日： 2009-03-03
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公开(公告)号： US20110229495A1公开(公告)日： 2011-09-22
- 发明人: David H. Wagner
- 申请人： David H. Wagner
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; G01N33/566 ; A61K38/02 ; A61K31/7105 ; A61K38/10 ; A61K38/16 ; A61K31/352 ; A61P37/02
摘要：
The present invention provides a new method for the prediction of, or diagnosis of, auto-immune diseases, thereby alerting the subject to the presence of, or propensity to develop, an auto-immune disease so that preventative or therapeutic regiments may be initiated or changed so as to treat, modulate or prevent expansion of the CD4loCD40hi T cell population responsible for the destructive inflammation. The invention also discloses agents which modulate, treat or prevent expansion of CD4loCD40hi T cells. In one embodiment, the method is predictive of type 1 diabetes.