Registration and inspection systems and methods for use on a winder are disclosed. The systems and methods include scanning a region proximate a winding module with one or more sensors to determine a product defect. The product defect is then associated with a winding process parameter, such as percent roll build information or the identity of the particular sensor to first detect the defect. The winding process parameter is used to classify the defect into one or more defect profiles. The defect profiles can be based at least in part on segmenting the roll build of a web onto a winding module into a plurality of inspection windows and segmenting a plurality of sensors into a plurality of inspection sensor segments.