发明申请
- 专利标题: BIOCOMPATIBLE POLYMERS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
- 专利标题(中): 生物易燃聚合物,其制备方法及其组合物
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申请号: US13160099申请日: 2011-06-14
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公开(公告)号: US20110243881A1公开(公告)日: 2011-10-06
- 发明人: Denis Barritault , Jean-Pierre Caruelle
- 申请人: Denis Barritault , Jean-Pierre Caruelle
- 优先权: FR98/09309 19980721
- 主分类号: A61K31/795
- IPC分类号: A61K31/795 ; A61K31/721 ; A61P9/10 ; A61P39/06 ; A61P9/00 ; A61P25/00 ; A61P17/00
摘要:
A process for treating fibroses including administering a therapeutically effective amount of a pharmaceutical composition which includes at least one biocompatible polymer of the following general formula (I): AaXxYy wherein: A represents a monomer selected from the group consisting of a sugar or —(O—CH2—CH2—CO)—, X represents a carboxyl group bonded to monomer A and is contained within a group according to the following formula: —R—COO—R′, in which R is a bond or an aliphatic hydrocarbon chain, optionally branched and/or unsaturated, and which can contain one or more aromatic rings except for benzylamine and benzylamine sulfonate, and R′ represents a hydrogen atom or a cation, Y represents a sulfate or sulfonate group bonded to monomer A and is contained within a group according to one of the following formulas: —R—O—SO3—R′, —R—N—SO3—R′, —R—SO3—R′, in which R is a bond or an aliphatic hydrocarbon chain, optionally branched and/or unsaturated, and which can contain one or more aromatic rings except for benzylamine and benzylamine sulfonate, and R′ represents a hydrogen atom or a cation, a represents the number of monomers A such that the mass of the polymers of formula (I) is greater than approximately 5,000 da, x represents a substitution rate of the monomers A by the groups X, which is between approximately 20 and 150%, and y represents a substitution rate of the monomers A by the groups Y, which is between approximately 30 and 150%.
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